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DiabetesIndia 2022: A Silver Lining in the Armamentarium of Diabetes Therapy: The Birth of the World’s First “Peptide in a Pill”

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Dr Rajiv Kovil, Mumbai    26 June 2022

  • Peptides are challenging compounds and require engineering to optimize their in vivo
  • Peptide analogs can be designed to offer improved stability and prolonged t1/2 while a formulation approach can facilitate improved absorption.
  • Absorption of oral semaglutide takes place in the stomach and requires coformulation with SNAC.
  • The mechanism of absorption is shown to be compound-specific, transcellular and without any evidence of an effect on tight junctions.
  • The development of “peptide in a pill-oral semaglutide” represents an advancement in treatment possibilities for chronic diseases by transforming injectable therapies into tablet-based oral formulations.

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